Magnesium Krebs Cycle Formula

Feature summary

Is getting enough magnesium as important as getting enough calcium? Yes. Magnesium is the fourth most abundant mineral in the body, required for development and maintenance of bones and teeth, nervous system and muscle function and for normal heart rhythm. It facilitates the actions of more than 300 enzymes. Nuts and green vegetables are good sources of magnesium but North Americans tend to eat more processed foods resulting in many people not getting the recommended daily intake of magnesium (420 mg/day for men over 30; 320 mg/day for women over 30).

What is the Krebs Cycle?

The Krebs cycle is a biochemical action that occurs in every cell of the body and produces most of the body’s energy (called APT). Organic acids needed for the Krebs cycle are bound to the mineral magnesium to enhance the mineral's bioavailability. Magnesium presented as Krebs cycle sources (citrate, fumarate, succinate, malate, glucarate) is more absorbable than the pure carbonate or oxide forms in people with insufficient stomach acid because the molecules breakdown easier without the need for stomach acid.  

Research in brief

Supplemental magnesium (Mg) in its citrate from is more bioavailable than magnesium oxide. Mg citrate has high solubility even in water, with a pH of 7. Most commercially available magnesium is Mg oxide, which has low solubility even in acid solutions. (3)Research shows that low magnesium levels contribute to common health problems, including high blood pressure, cardiovascular disease, metabolic syndrome, osteoporosis and migraine headaches, which may be the consequence of cumulative low magnesium levels.  Magnesium deficiency is common, especially among women and seniors. Certain medications can compound Mg deficiency, including diuretics, antibiotics, and health conditions like Crohn’s disease and alcoholism.  
Magnesium is very safe because any excess is excreted in the urine. People with kidney problems, kidney disease and heart patients should not take magnesium supplements without their physician's approval. Seniors who take multiple magnesium-containing laxatives and antacids may develop toxicity symptoms if they also supplement with magnesium.

Research in brief references

1. http://ods.od.nih.gov/factsheets/magnesium.asp. Accessed Feb 16, 2010.

2. Health Canada. Natural Health Product Directorate. Single Product Monograph. Magnesium. http://webprod.hc-sc.gc.ca/nhpiddipsn/monoReq.do?id=123&lang=eng. Accessed Feb 14, 2010.

3. http://www.wnpharmaceuticals.com. Product Monograph. Magnesium Citrate. Accessed Feb 15, 2010.

Medicinal ingredients

Elemental magnesium 500 mg  (Oxide and Krebs Cycle Sources: citrate, fumarate, succinate, malate, glutarate)

Non-medicinal ingredients

Microcrystalline cellulose, coating (carbohydrate gum, polyethylene glycol, titanium dioxide, polydextrose, triacentin), croscarmellose sodium, vegetable grade magnesium stearate (lubricant).